And susceptibility to inflammatory bowel diseases and colorectal drehdphones cancer Relationship between the polymorphism of tumor necrosis factor g and susceptibility to inflammatory bowel diseases and colorectal cancer:A metaanalysis Wang fan1, wang maoqing2, chen wangyang3, hu fulan1, li dandan1, ren jiaojiao1, dong xinshu4, cui binbin4 and zhao yashuang1 1Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, PR China2Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, PR China3Department of Epidemiology, Institute of Cancer Prevention and Treatment, Harbin Medical University, Harbin, Heilongjiang Province, PR China4Department of Abdominal Surgery, Tumor Hospital, Harbin Medical University, Harbin, Heilongjiang Province, PR ChinaCorrespondence:Dr z yashuang, department of epidemiology, school of public health, harbin medical university, harbin, heilongjiang province, pr china. Top of pageabstractinflammatory bowel disease(Ibd)And colorectal cancer(Crc)Are common health problems worldwide.Tumor necrosis factor(Tnf)Is a type of cytokine that indUces inflammation and inhibits tumorigenesis.Several studies have assessed the relationship between the polymorphism of tnf g and the susceptibility to ibdAnd crc;However, the results have been controversial.In addition, the hypothesis whether the increased risk of crc in ibd patients could be partly ascribed to the polymorphism of tnf g was unclear.Therefore, we condUcted this metaanalysis to confirm these associations.Pooled odd ratios(Ors)And 95 confidence intervals(95 CIs)Were calculated on the basis of data from 14, 18, and 7 studies from a total of 27 studies for the associations between the polymorphism of tnf g and ulcerative colitis, crohn's disease(Cd)And crc.In europeans, the aa genotype increased the risk of ulcerative colitis(Uc) (Or, 2.041;95 CI, 1.261 and CD(Or, 1.730;95 CI, 1.168 significantly, without obvious heterogeneity and publication bias.Meanwhile, the ga genotype increased the risk of uc in asians(Or, 2.360;95 CI, 1.269 significantly.However, no significant association was observed for crc in any ethnic population.The results of this metaanalysis suggested that the polymorphism of tnf g participates in modifying the susceptibility to uc and cd in europeans and asians.The increased risk of crc in ibd patients should be clarified as the combined effects of polymorphisms in tnf and other cytokines, and the interaction with environmental factors, in future studies. Keywords:Tumor necrosis factor crohn's disease;Ulcerative colitis;Inflammatory bowel disease;Colorectal cancer Top of pageintrodUctioninflammatory bowel disease(Ibd)Refers to two chronic diseases caused by an inflammatory condition of the intestine:Ulcerative colitis(Uc)And crohn's disease(Cd).Extensive studies have suggested that ibd is a multifactorial disease that has arisen from both environmental risk factors and genetic susceptibility.5, 6 Previous genetic association studies mainly focused on the relationship between IBD and the genetic variants in HLA genes instead of on genes involved in immune regulation and inflammatory response.Recent identification of polymorphisms in the tumor necrosis factor(Tnf gene gave suggestions on understanding the genetic predisposition of these two diseases.7, 8 The human tnf gene was first cloned in 1985.It maps to chromosome 6p21.3 and encodes a multifunctional proinflammatory cytokine that belongs to the TNF superfamily.Tnf has several actions, such as stimulating the acute phase response, leading to an increase in the level of creactive protein, and producing Il1 oxidant and inflammatory lipid prostaglandin e2.Large amounts of tnf are released in response to lipopolysaccharides, other bacterial products, and interleukin1(Il1). Studies have highlighted that small differences at cytokine levels as a result of genetic variants may have an important effect on inflammatory response and may influence the pathophysiology.Two snps located at nucleotides and have been extensively researched on the susceptibility to a range of autoimmune disorders, including rheumatoid arthritis, 9 exfoliation glaucoma, 10 and many kinds of cancers.11, 12, 13 The hypothesis that TNF G may have important roles in the development of UC, CD, and CRC has been debated.The results of previous association studies were inconsistent.Moreover, whether the increased risk of crc in ibd patients could be partly ascribed to the polymorphism of tnf remains unclear.Therefore, to further explore the relationship between the promoter g polymorphism in tnf and the risk of uc, cd, and crc, we conducted a systematical review and a metaanalysis. Top of pagematerials and methods Search strategypubmed, cochrane and embase were retrieved for the association studies focused on the relationship between the polymorphism of tnf g and the risk of ibd and crc primarily.Only the fulltext papers published in english were included. Criteria of inclusionAndexclusionany human association study, regardless of sample size, was eligible(1)If it pertained to1 the relationship between the polymorphism of tnf gAndthe risk of ibd or crc; (2)The genetic information of included studies was from unrelated populations; (3)Controls of included studies were from a healthy population or were subjects without diseases related to ibd or crc; (4)The genotype distribution of the control population was in hardy equilibrium;And(5) for the articles with overlap data of the same population resource, only the latestAndlargest report was included. Baseline informationAnddata were extracted by two reviewers independently using the same standard. In addition, the quality of studies was assessed by these two reviewers adopting the quality assessment score method, which was based on traditional epidemiological considerationsAndgenetic issues.14 Another reviewer adjudicated the differences between them. Statistical analysisvariant allele frequencies were compared between cases and controls in different ethnic populations.Compared with wildtype homozygote gg, ors, and 95 cis for the heterozygote ga and the variant homozygote aa were calculated, respectively.The relationship between the polymorphism of tnf g and the risk of uc, cd, and crc was further analyzed by categorizing into different ethnic populations.The associations with p were considered as being statistically significant.Homogeneity among the included studies was assessed using the cochrane q value and i2.When obvious heterogeneity was detected, a randomeffects model was used;Otherwise, a fixedeffects model was adopted.Publication bias was investigated using graphical evaluation of funnel plots.In addition, the possible presence of publication bias was assessed by rank correlation and linear regression.If significant publication bias was detected, ors and 95 cis would be adjusted by trim and fill. Analyses were performed with the software spss(13.015, Permanent licence, Stats Data Mining Co., Ltd, Beijing, China).Ors and 95 cis were generated by cma(Comprehensive meta analysis v2(2005)Biostat, inc., Englewood, NJ, USA). ToPof pageresultsmain characteristics of included studiesdetails beats by dre uk for literature search were shown in figure 1.Finally, 27 studies were included in this metaanalysis.Six of them were on asians, and the others were conducted on a european population.In all, 25 of the 27 studies were populationbased case studies, except for two hospitalbased case studies.Data were obtained from 14, 18, and 7 studies for the association between the polymorphism of tnf g and uc, cd, and crc, respectively.Genotype and variant allele frequencies were presented in table 1in these included studies, ibd patients were diagnosed with conventional pathological examination or selected from definite cases in the hospital.Crc patients were confirmed by histological diagnosis.All cases were matched with unrelated healthy individuals or volunteers recruited from the same ethnic population.In these 27 studies, pcrrflPor pcrsscPwas chosen for genotyping in 18 studies, and realtime pcr assays with(Taqman, life technologies corporation, carlsbad, ca, usa)Primers and probes were used in the others.No statistically significant differences in variant allele frequencies between cases and controls were found in either europeans(Por asians(P(Table 2).Compared with asian controls(Mean 0.052 European controls carried a higher frequency(Mean 0. 174 Pof the allele (Table 2).There were no significant associations for the comparisons of ga vs gg and ga vs gg in these two ethnic populations.As only one study carried out in asians was included, onesample ttest was used to compare the differences of allele frequencies between european and asian controls(PNo significant association was observed between the polymorphism of TNF G and the risk of CRC.Most ors and 95 cis adjusted by the trim and fill method were listed in table 3. As shown in figures 2a and b, the graphics of funnel plot revealed that no publication bias in the dominant genetic model was observed in the total analysis of uc and cd.Only the funnel plot of crc was asymmetrical and adjusted by the trim and fill method(Figure 2c).Rank correlation and the linear regression approach have also been used to evaluate potential publication bias.Detailed results are listed in table 3.
Crucial tips on how to get cheap christian louboutin pas cher designer bags It is one of those handy fashion accessories people, especially women, cannot do without.Handbags are known for their appeal and sophistication that does not compromise on their functionality as they are very handy when it comes to carrying everyday items like cell phone, wallets, keys, tissues etc.Carrying a handbag is easy, but the real challenge lies on how to find cheap designer bags especially in such tumultuous economic times. The good news is that you can find cheap bags if you know where to search.The first thing that you should know however before you even get started is to have an open mind.Note that if you are looking for a specific style of bag, or a specific brand name, you may not necessarily locate it immediately as it could be out of stock or something.But with an open mind, you can be sure to find something equal, or even much better than what you wanted initially. The first place to check would be in a local designer handbag shop.Naturally, if there is new stock expected, there mozongo would be a clearance sale on all the current handbags so as to free up some space and avoid having dead stock.This could be a godsend opportunity to get a good quality bag at a great price. By the same token, you could also get yourself a great piece at a great price if you bought your handbag offseason.For instance, you can buy a summer handbag that is 'outofseason' during winter and store it so you can use it christian louboutin platforms sale during the summer.Sometimes stores give up to 50% discounts of all outofseason bags which needless to mention, is an unimaginable saving. Did you know that you can also find cheap designer handbags online?Yes, you can but you have to be very careful when shopping online.Unlike a physical store where you can physically examine the authenticity of the handbag before acquiring it, it poses a challenge buying online because all you have are the pictures, and you might end up paying for an expensive replica of the same. This should not be construed to mean that replica designer bags are bogus;What it means is that you should be very careful not to pay more than its actual worth.The best way to go about it is to ensure you visit reputable handbag online stores, preferably those run by the real manufacturers, or those affiliated to the real manufacturers. This way, you will be guaranteed of getting your money's worth.The best thing about buying these bags online is that they are always discounted for the obvious reason that there is no rent or employees to pay hence the saving always trickle down to consumers, and you end up making a great bargain. Designer handbags have been the reserve of the rich and mighty of the society, but not anymore as there are pieces in the market to suit all budgets.
'The Hangover Part Preceding its memorial day opening, the hangover part 2 had its big premiere at grauman's chinese theatre.On may 19, bradley cooper, zach galifianakis, ed helms, and crystal the monkey, joined the rest of the cast in los angeles. Photo miaelkorssaleonline source:Eyeprime The hangover part 2 actresses jamie chung, and sasha barrese more than made up for the questionable premiere attire of their male coactors.Sucker punch's jamie always manages to wear revealing clothes without looking like she's trying too hard.Her sexy julien macdonald dress resembled fine chain mail, and the fringed panels on each side showed quite a lot of skin.Jamie wisely downplayed everything else with nude louboutin pumps, and loose wavy hair. Photo source:Eyeprime Kristen bell attended the premiere with her fianc iaelorshandtasenswarz dax shepard.The actress looked lovely in a j.Mendel frock.The pastelcolored draped dress suited kristen well, as did her leglengthening brian atwood heels.
Ancient roads and gps survey A wide area without the encumbrance a burden, obstruction, or impediment on property that lessens its value or makes it less marketable.An encumbrance(Also spelled incumbrance)Is any right or interest that exists in someone other than the owner of an estate and that restricts or impairs the transfer of the estate or of subsequent occupation. The city is located on the nile, drdrebts about halfway between the Important centres of memphis and beats by dre outlet uk thebes.It lies mainly on the east Bank, on a flat piece of desert which is surrounded by a crescentshaped Escarpment escarpment or scarp, long cliff, bluff, or steep slope, caused usually by geologic faulting(See fault)Or by http://www.teamskyuser.co.uk/beats-by-dr-dre-pro.html erosion of tilted rock layers.An example of a fault scarp is the north face of the san jacinto mts.In california.In the central part(Figure 1)Is a temple and ceremonial Centre, with surrounding accommodation for the city's officials, Workers and citizens.The escarpment itself contains rockcut tombs Attributed to the more prominent inhabitants.Akhenaten marked the Limits of his city by placing boundary stelae both on this eastern Escarpment, and on the distant escarpment on the western bank of the Nile.In the area between the main city and the eastern escarpment lies An area of desert which at first viewing would appear to be devoid of Activity.It is on this area that the new survey work reported here wasflinders petrie professor sir william matthew flinders petrie frs(3 June 1853 28 July 1942), known as Flinders Petrie, was an English Egyptologist and a pioneer of systematic methodology in archaeology.Conducted the first archaeological investigations
Counterfeit air bags pose 'extreme safety risk' to drivers Washington thousands of motorists may be driving cars and trucks installed with dangerous counterfeit bags and they should have them replaced at their own expense, the obama administration warned wednesday. Most at risk are motorists who have had their airbags replaced over the past three years by a repair shop other than a new car dealership, the national highway traffic safety administration officials said.Vehicle fleet about 250, 000 cars on the road are makes and models for which counterfeit airbags are known to be available, nhtsa said.Auto industry officials briefed by the agency said they were told that tens of thousands of car owners may be driving vehicles with counterfeit airbags. In government tests last month of 11 counterfeit bags, 10 didn't inflate or failed to inflate properly.In one test, a counterfeit bag shot flames and shards of metal shrapnel at a crash dummy instead of inflating, said nhtsa administrator david strickland, who showed a video of the test at a news conference. "It is an extreme safety risk,"He said. No deaths or injuries have been tied to the counterfeit bags, nhtsa said.But it's unclear whether police accident investigators would be able to identify a counterfeit bag from a genuine one, industry officials said. About 1.5 million airbags are deployed each year in policereported towaway crashes, Clarence Ditlow, executive director of the Center for Auto Safety, said. "Airbags save several thousands of lives christian louboutin platforms online annually.But they can't save lives if they have not been repaired properly,"He said. Nhtsa has compiled a list of dozens of vehicle makes and models for which counterfeit airbags may be available, but the agency cautioned that the full scope of the problem isn't clear yet and the list is expected to"Evolve over time. " If a car model is on the list and has had its airbags replaced during the past three years by a repair shop other than a new car dealership, nhtsa is asking owners to take the vehicle into a dealership or repair shop to be inspected at their own expense to determine whether the replaced airbags are counterfeit. Fees for checking out airbags a complex and technical process could run between $100 to $200, said bailey wood, a spokesman for the national automobile dealers association, said.The cost of replacing a driver's side center column airbag is $750 to $1, 000, he said.Other airbags may be more, he said.Some types of cars have as many as eight airbags. The problem isn't the result of a manufacturing defect by automakers and isn't a recall, nhtsa and industry officials said. louboutin pas cher "The bad actor here is the counterfeiters,"Wood said. "Because of that, the cost to have an airbag evaluated and possibly replaced is going to be borne by the consumer. " The counterfeit bags typically look like airbags made by automakers and usually include a manufacturer's logo.Government investigators believe many of the bags come from china, an industry official said. The bags are marketed to auto repair and body shops as the real deal, industry officials said.Auto dealerships that operate their own body shops are usually required by their franchise agreements to buy their parts, including airbags, directly from automakers and therefore are unlikely to have installed counterfeit bags, industry officials said. But only 37 percent of auto dealers have their own body shops, according to the automobile dealers association.Many consumers whose vehicles have been damaged are referred by their insurance companies to auto body shops that aren't affiliated with an automaker. Consumers who bought replacement airbags online or who have purchased a used car that may have its airbags replaced in the past three years were also asked to check nhtsa's ristianlbtinaussures list. Counterfeiting of a wide variety of auto parts has long been a wellknown problem, industry officials said.But recent incidents have escalated concern by government officials.In august, federal agents confiscated nearly 1, 600 counterfeit airbags and arrested a north carolina auto mechanic, according to a report by the charlotte observer.The mechanic was tied by federal officials to another counterfeit airbag case last year in tennessee, the report said.Attorney's office. Zhensong was a part owner and manager of the international department of guangzhou auto parts, which made a variety of auto parts, many of which were counterfeit, the statement said.In 2010, he traveled from china to chattanooga to sell additional counterfeit airbags and other auto parts. The counterfeit airbags were manufactured by purchasing genuine auto airbags that were torn down and used to make molds to produce the counterfeit bags.Trademark emblems were purchased through honda, toyota, audi, bmw and other dealerships located in china and affixed to the counterfeit airbags.The airbags were advertised on the guangzhou auto parts website and sold for approximately $50 to $70 each, far below the value of an authentic airbag, the statement said.
Sue your competition That the question at the heart of a legal battle between french shoemaker christian louboutin, designer of the iconic, skyhigh, redsoled shoes worn by celebrities like oprah and angelina jolie, and yves st.Laurent, the fashion powerhouse launched in 1962 that now sells everything from lipstick to luggage and occasionally, redsoled shoes. Louboutin tried to slap ysl with an injunction in april, to prevent the company from selling footwear with red soles, including a platform shoe that is red all over. Is seeking to take unfair advantage of the enormous goodwill and brand recognition in the red sole mark that we have developed over the past two decades, according to legal documents filed by lawyers representing louboutin in a new york city district court in april. Ysl countered by pointing out that red outsoles were popular in the french court of louis xiv in the 1600s, that dorothy wore red shoes in the wizard of oz in 1939, and ysl has made shoes with red on the sole as far back as the 1970s and every year since 2003. Attempt to monopolize the use of red outsoles, even to the extent of claiming that no other designer can make an allred shoe is unsupported by law, defies common sense and would unduly restrict the design options available to competitors in the market, according to ysl counterclaim. Both brands sell for upwards of $600 a pair. Louboutin is claiming $1 million in damages from ysl.In return, ysl is seeking damages in a counterclaim, alleging that louboutin pressured retailers to return the redsoled ysl shoes and to stop selling all ysl footwear. District court judge victor marrero refused to grant louboutin the injunction, waxing poetic about the role of colour in art and fashion. That monet, having just painted his water lilies, encounters a legal challenge from picasso.Picasso alleges that monet, in depicting the colour of water, used a distinctive indigo that picasso claims was the same or too close to the exquisite shade that picasso declares is colour of melancholy, the hallmark of his blue period, marrero wrote in his decision. Allowing one artist or designer to appropriate an entire shade would unduly hinder not just commerce and competition, but art as well, according to michael kors outlet usa marrero. Louboutin has appealed the decision. The claim and counterclaim are rife with insights into the competitive world of luxury fashion. In their original claim, lawyers for louboutin, who lives in paris, described the iaelorssaletasen lengths he went to propel louboutin into the celebrity stratosphere and keep it there. To maintain demand, louboutin often will not fill a vendor entire order, preferring instead to keep the product in short supply, making it out from time to time. Thus watch carefully for all deliveries and often are on waiting lists for new product, according to the court documents. Rather than pay for advertising, louboutin lends shoes out for fashion shoots and to celebrities appearing in only the best magazines publications are screened to ensure they have the right readership, photo content and advertising. Louboutin press offices around the world maintain a large inventory of shoes in every colour, size and model, in order to fill requests from approved celebrity stylists and media in one or two days.All shoes must be returned. Have made the conscious effort to keep louboutin footwear as a recognized luxury item and thus away from what is commonly known as mainstream marketing, reads the lawsuit. Louboutin footwear has become synonymous with luxury fashion, and as a result, is not only coveted by people can readily afford them, but also by priceconscious.Louboutins were also featured in the sex in the city series and movies.Oprah often wore them on her talk show.Jennifer lopez released a single called in 2009, and yes, she wears them. Louboutin says he launched his first shoe store in 1991, came up with the idea of a lacquered red sole in 1992 and trademarked it in 2008.Ysl alleges the trademark was fraudulently obtained because louboutin claimed the red lacquered sole was exclusive to his shoes when in fact, red soles have been used by other shoemakers. Sarah borg, assistantcurator at the bata shoe museum says louboutin red soles are iconic, but that doesn mean he should have the exclusive right to the idea. He gets red soles, then who gets to only do black soles, or only do blue soles?I think it a slippery slope, she said. Borg compares the redsole fashion statement to the reign of louis xiv, who decreed only members of his french court could wear shoes with red heels. Not new as a concept to enforce elitism, which is what he doing, borg says, of louboutin. David markowitz, president and ceo of davids footwear, says louboutins are one of his most popular lines.The red soles in theWindow beckonWomen into the flagship store at 66 bloor st.W.At bay st. Some save forWeeks to buy Louboutins, he says. Opinion is that the red sole is very similar to a logo or a brand name and christian louboutin developed the red sole and created the buzz about it.It their concept, they deserve ownership.
An example of nutrigenetics visithomepage in crohn's disease Catarina sousa guerreiro bsc, ms1, paula ferreira bsc2, lourdes tavares md3, paula moura santos md3, manuela neves bsc, phd4, miguel brito bsc, phd2 and mar cravo md, phd51department ofDietetics, escola superiorDe tecnologiaDa saDe lisboa, unidadeDe nutri e metabolismoDo institutoDe medicina molecularDa universidadeDe lisboa, lisboa, portugal2escola superiorDe tecnologiaDa saDe lisboa, lisboa, portugal3serviDe gastrenterologiaDo hospitalDe santa maria, epe, lisboa, portugal4instituto superiorDe agronomia,DepartamentoDe matem lisboa, portugal5serviDe gastrenterologiaDo instituto portuguDe oncologiaDe lisboa francisco gentil, epe, lisboa, portugalcorrespondence:Catarina sousa guerreiro, cientificaDeDiet escola superiorDe tecnologiaDa saDe lisboa, av.D.Jo ii, lote 4.69.01 1990096 Lisboa, Portugal.Top of pageabstractobjectives:The aim of this work was to study the interaction between genetic polymorphisms(Singlenucleotide polymorphisms, snps) of pro and antiinflammatory cytokines and fat intake on the risk ofDeveloping Crohn'sDisease (Cd) or modifyingDisease activity.Methods:Seven snps in interleukin 1(Il1), tumor necrosis factor alpha(Tnf lymphotoxin alpha(Lt and il6 genes were analyzed in 116 controls and 99 patients with cd. The type of fat intake was evaluated, and the interaction between SNPs beats by dre online store uk andDietary fat in modulatingDisease activity was analyzed. Finally, low intake of n3 PUFA and high n6 PUFA ratio in patients with the TNF 857 polymorphism were associated with higherDisease activity (Or 95 ci or 95 ci respectively).
Corde calvin broadus So, the family that tokes together, uh, jokes together?Maybe.Not everyone was amused, though.Celebrity baby scoop clucked its tongue, calling the pictures"Controversial,"And hollywoodlife went so far as to call snoop a"Bad christian louboutin pompes pas cher father. " Still.It's hard, as the blog crushable points out, to get too worked up over this. After all snoop, who recently converted to christian louboutin chaussures soldes rastafarianism and changed his name to snoop lion, first gained notoriety by spitting heavylidded rhymes on an album called the chronic.Are we that shocked that a man who has so publicly embraced all things sticky and icky would share his passion with his son?At the very least, he's no hypocrite. Plus:Boy brings 9 bags of lbtinpaser marijuana to school Snoop is by all accounts an attentive and involved father.For two seasons he strutted his unorthodox parenting steez on the e!Reality show snoop dogg's father hood.The man's a community youth football coach.Perhaps people should make more noise over his enthusiastic embrace of his role as a father than his outre lifestyle choice.And, hey, at least he's not this guy.
Shoe party fundraiser louboutin red soles shoe iaelorsonlineshopdeutsland raffle .This organization ro, give fundraising events for the community to support parents whom have been unemployed since 2008 with small children(Ages 413)In need of clothing and shoes, for their child to return to school and other events throughout the year.This group of people is called the '99ers, by the government media.With the unemployment over 12% in most states, ro realizes the length of the unemployment check, after monthly bills, it leaves nothing for children clothing and shoes.We work very hard to provide relief to families in this down economy receiving unemployment benefitsthis year we will have our"Female shoes fundraising"Event to raise funds to purchase clothing and shoes for unemployed families.Do you remember going back to school with something new, giving you confidence, feeling good and making new friends?I know i do.Even if the school is a uniform system, they will have on new shoes.I hope we can count on you for a generous donation of $10.00 or more;Even if you cannot attend.Donations of $100.00 or more will be entered into (2)RaffleDrawings for the"Christian louboutin", red soles shoe raffle(Value at $800.00)Drawing.Giving 2 people a chance to win. ThisDrawing will be held the evening of the event and you do not have to be present.The winner will be contacted by email and phone to receive their christian louboutin shoes gift certificate.Donations miaelkorssaleonline of $25.00 or more will will be entered in the "Top designer's shoe"Raffles. (4)RafflesDrawing will be held. These shoeRaffles have a retail value of $150$300.Donations of $10.00 to $20.00 will enter you into the regular raffle and receive a pair of shoes, IF you should attend the event in person.Let's not forget most of them have young children at home that has out grown clothing and shoes, some are living in their cars, bed bug motels across the country, some are spending their nights sleeping on park bunches, and some have no hope left and have giving up.
Amgen 3q report to focus on key drug sales trends Thousand oaks, calif. (Ap)Amgen inc., the world's largest biotech company by revenue, likely beats by dre sale cheap will focus on sales prospects for its top drugs and progress on its experimental drugs when it reports thirdquarter results after the stock market closes Monday. What to watch for:The maker of neulasta, for preventing infections in chemotherapy patients, should discuss how much recent safety warnings could dampen sales for two of amgen's top four drugs.Such biologic drugs, which are produced in living cells, are very powerful but can cause serious side effects. In june, the food and drug administration said doctors should use lower doses of anemia drugs when treating patients with failing kidneys because of increased risk of stroke, blood clots and death.That will affect sales of amgen's aranesp and epogen.In the second quarter. Epogen also faces new limits on reimbursement proposed for patients covered by medicare and medicaid.The company has said that if the federal government imposes those limits, on top of the new safety warnings, it could beats by dre uk wireless reduce epogen use by 20 percent to 25 percent.Last november.Xgeva, which is used to prevent fractures in patients whose cancer has spread to bones, blocks the breakdown of bone cells.Sales of $115 million for the first six months of the year. Xgeva has already exceeded sales for prolia, a slightly older osteoporosis drug with the same active ingredient but a different dosage.Prolia was launched for preventing fractures in june 2010.In midseptember, it got approval from the food and drug administration for use in two patient groups at high risk of fracture:Women getting hormone therapy for breast cancer and men getting hormone therapy for prostate cancer.That should boost future sales. Amgen is now seeking approval to market xgeva for men with prostate cancer, to prevent spread of cancer to bones. The company is awaiting approval in europe for its vectibix, for advanced colon cancer in patients with a certain genetic mutation.And some foreign markets. Amgen executives may discuss integration of cancer therapy developer biovex group, which is developing oncovex for treating malignant melanoma.In july, amgen said it had temporarily halted another study of oncovex, for treating head and neck cancers.Amgen bought the company in march.Government reimbursements for some of amgen's key drugs could hurt sales.Sales on wednesday.Both drugs are in the class known as antitnf agents;They target a substance called tumor necrosis factor that causes inflammation. What's expected:Analysts polled by factset, on average, expect earnings per share of $1.29 on revenue of $3.87 billion. Last year's quarter:Amgen reported an 11 percent drop in income to $1.24 billion, or $1.28 per share, on revenue of $3.82 billion.Default?Bloomberg readies for earthquake.Literally.'AntiBreaking drebtshdphones Bad':Man seeks to fight cancer diagnosis with help from around the world onearmed dj's inspirational story
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